Cellular and molecular mechanisms of calcific aortic valve disease
نویسندگان
چکیده
منابع مشابه
Molecular and cellular aspects of calcific aortic valve disease.
Calcific aortic valve disease (CAVD) increasingly afflicts our aging population. One third of our elderly have echocardiographic or radiological evidence of calcific aortic valve sclerosis, an early and subclinical form of CAVD. Age, sex, tobacco use, hypercholesterolemia, hypertension, and type II diabetes mellitus all contribute to the risk of disease that has worldwide distribution. On progr...
متن کاملCalcific aortic valve disease: cellular origins of valve calcification.
Calcific aortic valve disease is the most common indication for surgical valve replacement in the world.1 For years this disease was thought to be a passive degenerative phenomenon. Understanding of the cellular mechanisms of this valve lesion will present new cellular therapeutic options to slow disease progression. In this study by Egan et al,2 they identify for the first time in human calcif...
متن کاملCalcific Aortic Valve Disease
Aortic stenosis due to calcific aortic valve disease (CAVD) is currently the main indication for aortic valve replacement in developed countries (Iung et al, 2003). Due to an aging population and a decline in rheumatic heart disease, CAVD has become the most common heart valve disease in the Western countries, affecting approximately 25% of adults over 65 years, of which 2-3% has clinically sig...
متن کاملCalcific Aortic Valve Disease
Despite the high prevalence and severe consequences of calcific aortic valve disease (CAVD), its pathogenesis remains relatively poorly understood. For many years, CAVD was considered a degenerative disease, where calcification was a consequence of normal aging. Although it is now widely accepted that CAVD is an active disease process, the erroneous degenerative label contributed to delayed pro...
متن کاملHemodynamic and cellular response feedback in calcific aortic valve disease.
This review highlights aspects of calcific aortic valve disease that encompass the entire range of aortic valve disease progression from initial cellular changes to aortic valve sclerosis and stenosis, which can be initiated by changes in blood flow (hemodynamics) and pressure across the aortic valve. Appropriate hemodynamics is important for normal valve function and maintenance, but pathologi...
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ژورنال
عنوان ژورنال: Russian Journal of Cardiology
سال: 2019
ISSN: 2618-7620,1560-4071
DOI: 10.15829/1560-4071-2019-9-86-91